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KMID : 0371619860020010035
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Journal of Wonkwang Medical Science
1986 Volume.2 No. 1 p.35 ~ p.42
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A Cytogenetic Study on the Effect of Acetaldehyde on the Human Chromosomes
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朴鍾鶴/Park, Jong Hak
朴承澤/韓斗錫/鄭然泰/Park, Seung Taek/Han, Du Seok/Chung, Yeun Tai
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Abstract
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To investigate the effect of acetaldehyde on the human chromosomes especially frequency and distribution of sister chromatid exchange, an attempt was made.
The results obtained were as follows :
The frequencies were found to be 17.98 ± 0.49, 12.97 ± 0.34, 10.98±0.26 and 7.24 ± 0.24 in treated with acetaldehyde 10-3, 5 x 10-3, 10-´ M and the control respectively.
Acetaldehyde produced the dose dependent increase of frequency of SCE.
The regions generally vulnerable to acetaldehyde were 1q23 in chromosome 1, 2g31 in chromosome 2 and 3g21 in chromosome 3. Among these regions, 2g31 in chromosome 2 was particularly susceptible to acetaldehyde
Most of these regions susceptible to acetaldehyde were corresponding to G-1 ight bands.
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